2,5-二特丁基对苯二酚 T7540

Product Introduction
Bioactivity


英文名: 2,5-Di-tert-butylhydroquinone

描述: 2,5-Di-tert-butylhydroquinone (BHQ) 是一种有效和选择性的内质网 Ca2+-ATPase 抑制剂，可调节5-LO 以及COX-2活性，IC50分别为 1.8 和 14.1 μM。

体外活性: BHQ shifted the voltage dependence of the steady-state inactivation curve to more negative potentials by 7 mV in the mid-potential of the curve, without affecting the activation curve as well as the time course of I(Ca(L)) inactivation.?Preincubation of the cells either with 10 microM cyclopiazonic acid, a SERCA inhibitor, or with 3 mM diethyldithiocarbamate, an inhibitor of intracellular superoxide dismutase (SOD), did not modify BHQ inhibition of I(Ca(L)).?On the contrary, this effect was no longer evident when SOD (250 u ml(-1)) was added to the perfusion medium.?Either in the presence or in the absence of cells, BHQ gave rise to superoxide anion formation, which was markedly inhibited by the addition of SOD.At micromolar concentrations, BHQ inhibits vascular I(Ca(L)) by giving rise to the formation of superoxide anion which in turn impairs the channel function.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (224.9 mM)


关键字: Cyclooxygenase | 2,5Ditertbutylhydroquinone | Inhibitor | LOX | inhibit | 2,5 Di tert butylhydroquinone | 2,5-Di-tert-butylhydroquinone | COX | Lipoxygenase

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途