岩藻多糖 T7544
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
500 mg | 9072-19-9 | ¥286.00 | 询底价 |
100 mg | 9072-19-9 | ¥133.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Fucoidan
描述: Fucoidan 是一种 α-淀粉酶和 α-葡萄糖苷酶的有效抑制剂,是一种生物特性多糖。 它具有抗凝血,抗肿瘤,抗氧化和抗脂肪特性。
细胞实验: The influence of fucoidan on B16 melanoma cells and cellular tyrosinase:Cell viability was examined by the cell counting kit-8 assay. Cellular tyrosinase activity and melanin content were determined using spectrophotometric methods and protein expression was analyzed by immunoblotting. Morphological changes in B16 melanoma cells were examined by phase contrast microscopy and apoptosis was analyzed by flow cytometry[1].
动物实验: In vivo, therapy experiments were conducted on Babl/c mice bearing breast cancer.?The tumor volume and weight were measured.?The number of apoptotic cells and microvascular density (MVD) in tumor tissues were assessed by TUNEL and CD34 immunostaining.?Immunohistochemical assays and ELISA assay were used to detect the expression of VEGF in tissues[2].
体外活性: Fucoidan在剂量反应方式下显著减少了活细胞数量,其IC50为550 ±4.3 μg/mL。当细胞暴露于550 μg/mL的Fucoidan下48小时时,细胞形态发生了变化,并且显著诱导了凋亡[1]。
体内活性: Intraperitoneal injection of fucoidan in breast cancer models reduced the tumor volume and weight.?The enhanced antitumor efficacy was associated with decreased angiogenesis and increased induction of apoptosis[2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: H2O : 10 mM
DMSO : Insoluble
关键字: polysaccharide | anticoagulant | diabetes | inhibit | Glucosidase | antisteatotic | Inhibitor | α-amylase | α-glucosidase. Antioxidant | Type 2 | anticancer | Fucoidan
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途