化合物LM22A-4 T7568

Product Introduction
Bioactivity


英文名: LM22A-4

描述: LM22A-4 是特异性的tyrosine kinase receptor B 激动剂，常用于研究神经系统疾病。

动物实验: Wt and Het littermates were divided into 4 groups: Wt vehicle-treated (100 μl of 0.9% NaCl, i.p., b.i.d.), Wt drug-treated (50 mg/kg LM22A-4 in 0.9% NaCl, i.p., b.i.d.), Het vehicle-treated (100 μl of 0.9% NaCl, i.p., b.i.d.), and Het drug-treated (50 mg/kg LM22A-4 in 0.9% NaCl, i.p., b.i.d.).?Each mouse was treated from 8 to 13 weeks of age.?Whole-body plethysmography was performed during week 12 and animals were subsequently killed and tissues harvested for TrkB Western blots and BDNF ELISA during week[1].

体外活性: In vitro, LM22A-4 increases survival of hippocampal neurons via activation of TrkB as well as Akt and ERK downstream pro-survival signaling pathways[1].

体内活性: 将Het小鼠用LM22A-4处理4周，能够在延髓和桥脑中恢复TrkB磷酸化的野生型水平，并且恢复了野生型的呼吸频率[1]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 50 mg/mL (147.34 mM)
DMSO : 29 mg/mL (85.46 mM)


关键字: LM-22A-4 | Inhibitor | Trk Receptor | inhibit | LM22A-4 | LM22A4 | Tropomyosin related kinase receptor | LM22A 4

相关产品: TRK-IN-24 | CE-245677 | 3,5,7,15-Tetraacetoxy-9-nicotinoyloxy-6(17),11-jatrophadien-14-one | Entrectinib | Repotrectinib | Danusertib | GNF-5837 | Protein kinase inhibitor 5 | ALE-0540 | Larotrectinib

相关库: Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | NO PAINS Compound Library | Bioactive Compound Library

化合物LM22A-4 T7568信息由TargetMol中国为您提供，如您想了解更多关于化合物LM22A-4 T7568报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途