化合物Lefamulin T7588

Product Introduction
Bioactivity


英文名: Lefamulin

描述: Lefamulin (BC-3781) 是一种半合成化合物，可抑制细菌生长所需的细菌蛋白质的合成。

体内活性: Lefamulin exhibits a unique mechanism of action through inhibition of protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome, thus preventing the binding of transfer RNA for peptide transfer. Lefamulin displays activity against gram-positive and atypical organisms associated with CABP (i.e., Streptococcus pneumoniae, Haemophilus influenzae, Mycoplasma pneumoniae, Legionella pneumophila, and Chlamydophila pneumoniae), with an expanded gram-positive spectrum including Staphylococcus aureus (i.e., methicillin-resistant, vancomycin-intermediate, and heterogeneous strains) and vancomycin-resistant Enterococcus faecium. Lefamulin was also shown to retain activity against multidrug-resistant Neisseria gonorrhoeae and Mycoplasma genitalium. Lefamulin exhibits time-dependent killing, and the pharmacodynamic target best associated with antibacterial activity is ?AUC0-24?/MIC (minimum inhibitory concentration [MIC]).

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (98.48 mM)


关键字: BC 3781 | Lefamulin | BC3781

相关库: FDA-Approved Drug Library | Drug Repurposing Compound Library | Approved Drug Library | FDA-Approved & Pharmacopeia Drug Library | EMA Approved Drug Library | Anti-Bacterial Compound Library | Preclinical Compound Library | Covalent Inhibitor Library | Anti-Infection Compound Library | Bioactive Compound Library

化合物Lefamulin T7588信息由TargetMol中国为您提供，如您想了解更多关于化合物Lefamulin T7588报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途