瑞他鲁肽 T76279
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
100 mg | 2381089-83-2 | ¥22,700.00 | 询底价 |
50 mg | 2381089-83-2 | ¥16,800.00 | 询底价 |
5 mg | 2381089-83-2 | ¥6,230.00 | 询底价 |
1 mg | 2381089-83-2 | ¥2,490.00 | 询底价 |
10 mg | 2381089-83-2 | ¥8,390.00 | 询底价 |
25 mg | 2381089-83-2 | ¥12,300.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Retatrutide
描述: Retatrutide (LY3437943) 是胰高血糖素受体、葡萄糖依赖性促胰岛素多肽受体和胰高血糖素样肽-1 受体三重激动剂,对GCGR、GIPR 和 GLP-1R 具有抑制作用。Retatrutide 可用研究肥胖症。
体外活性: Retatrutide (LY3437943) exhibits activity against human GCGR, GIPR, and GLP-1R with EC50 values of 5.79, 0.0643, and 0.775 nM, respectively[1].For mouse GCGR, GIPR, and GLP-1R, Retatrutide shows activity with EC50 values of 2.32, 0.191, and 0.794 nM, respectively[1].In terms of binding affinity, Retatrutide has Ki values of 5.6, 0.057, and 7.2 nM for human GCGR, GIPR, and GLP-1R, respectively[1].Similarly, for mouse GCGR, GIPR, and GLP-1R, Retatrutide exhibits binding affinity with Ki values of 73, 2.8, and 1.3 nM, respectively[1].
体内活性: In vivo, Retatrutide (LY3437943) engages with GCGR and, when administered through subcutaneous injection at a single dose of 0.47 mg/kg, improves glucose tolerance in an ipGTT (intraperitoneal glucose tolerance test) through activation of GIP or GLP-1 receptors[1].With subcutaneous injections at 10 mL/kg every 3 days in a cycle sustained for 21 days, Retatrutide leads to significant weight reduction and increased energy expenditure through activation of glucagon receptor[1].
存储条件: store at low temperature,keep away from moisturePowder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: H2O : 30 mg/mL (6.34 mM)
DMSO : 30 mg/mL (6.34 mM)
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途