塔法西他单抗 T77135

Product Introduction
Bioactivity


英文名: Tafasitamab

描述: Tafasitamab (XmAb5574) 是一种 Fc 修饰的人源化单克隆抗体，靶向人 B 细胞表面抗原 CD19 ，可用于研究弥漫性大B细胞淋巴瘤。

体外活性: In an E/T ratio-dependent manner, tafasitamab (XmAb5574) induced cytotoxicity to Mino and Jeko (MCL) cell lines. It also increased antibody-dependent cellular phagocytosis (ADCP) and antiproliferative activity. Additionally, tafasitamab (XmAb5574) can enhance the anti-proliferative activity induced by caspase-mediated apoptosis[1][2].

体内活性: In a xenograft tumor model of disseminated BL mice, tafasitamab (2.5 μg/kg, once on day 1) inhibited lymphoma growth[1].

存储条件: store at low temperaturestore at -20°C

关键字: MOR 00208 | Tafasitamab | MOR-00208

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途