氨基蝶呤 T7730

Product Introduction
Bioactivity


英文名: Aminopterin

描述: Aminopterin (4-Aminofolic acid) 是叶酸的 4-氨基衍生物，是叶酸拮抗剂，具有抗癌和免疫抑制活性，用于研究儿童白血病。它催化叶酸还原为四氢叶酸，竞争性抑制二氢叶酸还原酶，Ki 值为 3.7 pM。

体内活性: Aminopterin has anticancer and immunosuppressive properties. Formulations containing it have been used for pediatric leukemia though methotrexate is now more commonly used due to a more favorable therapeutic index[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 4.03 mg/mL (9.15 mM)


关键字: tetrahydrofolic | inhibit | anticancer | immunosuppressive | Aminopterin | acid | Antifolate | leukocytes | leukemic | folic | Inhibitor

相关产品: Pyrimethamine | Methotrexate | WR99210 | Metoprine | Trimethoprim | Calcium N5-methyltetrahydrofolate | Folinic Acid Calcium Salt Pentahydrate | Levomefolate calcium | Folinic acid | Farletuzumab

相关库: Anti-Aging Compound Library | Anti-Tumor Natural Product Library | Drug Repurposing Compound Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Inhibitor Library | Anti-Cancer Clinical Compound Library | Pediatric Drug Library | Anti-Cancer Active Compound Library | NO PAINS Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途