化合物DJ4 T77662

Product Introduction
Bioactivity


英文名: DJ4

描述: DJ4 在微摩尔范围内以剂量依赖性诱导促凋亡作用。

体外活性: In cellular functional assays, DJ4 inhibited migration of humanmelanoma, lung, pancreatic and breast cancer cells in a concentration-dependent manner. In live cellimaging over 20h by time-lapse microscopy, DJ4 (2.5 pM ) reduced the migration rate of lung-andbreast-cancer cells by 2.7 and 5.5 times compared to control cells respectively, DJ4 (5 pM) alsoinhibited invasion of MDA-MB-231 breast cancer cells by ~70%. Fluorescent microscopicobservation also revealed that inhibition of activity of these kinases, by DJ4, causes reduction instress fibers which leads to inhibition of cell contractility and migration.[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 5.63 mg/mL (16.05 mM)


关键字: DJ4 | DJ 4 | DJ-4

相关产品: Ispinesib | Tafasitamab | Pulsatilla saponin D | L-685458 | BIO-acetoxime | Busulfan | GSK-3β inhibitor 3 | Temsirolimus | (E)-Methyl 4-coumarate | [8]-Shogaol

相关库: Bioactive Compounds Library Max | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途