固绿 FCF T7772

Product Introduction
Bioactivity


英文名: Fast Green FCF

描述: Fast Green FCF (FD&C Green No. 3) 是海绿色三芳基甲烷食用染料，最大吸收在625nm 处，将在电泳过程中的蛋白质染色，。

体内活性: Pretreatment of Fast green FCF (100 mg/kg, i.p. daily for 7 days) alleviated depressive-like behavior in LPS-treated mice.?Fast green FCF suppressed the LPS-induced microglial and astrocyte activation in the hippocampus.?Fast green FCF decreased the mRNA and protein levels of Toll-like receptor 4 (TLR4) and Myeloid differentiation primary response 88 (Myd88) and suppressed the phosphorylation of nuclear factor-κB (NF-κB) in the hippocampus of LPS-treated mice.?Fast green FCF also downregulated hippocampal tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6, but did not alter the level of the brain-derived neurotrophic factor (BDNF) in the hippocampus of LPS-treated mice.?The molecular docking simulation predicts that Fast green FCF may interact with TLR4 and interrupt the formation of the TLR4-MD2 complex[1].

存储条件: keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 20 mg/ml
H2O : 10 mg/mL (12.36 mM)


关键字: Fast Green FCF | Food green-3 | Inhibitor | Food green3 | inhibit

相关库: Inactive Ingredient Library | Food Additive Library | Bioactive Compounds Library Max | Human Metabolite Library | Bioactive Compound Library

固绿 FCF T7772信息由TargetMol中国为您提供，如您想了解更多关于固绿 FCF T7772报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途