苯甲酸钠 T8124

Product Introduction
Bioactivity


英文名: Sodium benzoate

描述: Sodium benzoate (Benzoic acid sodium salt) 是一种 D-氨基酸氧化酶抑制剂。它是一种食品防腐剂。

动物实验: The study was carried out between July and September 2012 in the Laboratory Animal Center of Shiraz University of Medical Sciences, Shiraz, Iran. The rats were divided into 2 groups receiving distilled water and sodium benzoate (NaB)? (200mg/kg/day). All the animals received daily gavages for 4 weeks. At the end of the fourth week, anxiety, and motor function were assessed in elevated plus maze and rotarod test[2]

体外活性: At 24- and 48-hour. incubation time, sodium benzoate concentrations of 1.0, 1.5, and 2.0 mg/mL increased micronucleus formation when comparing with the control group (P < 0.05). At 24- and 48-hour. incubation time, sodium benzoate concentrations of 2.0 mg/mL increased chromosome break when comparing with the control group (P < 0.05). Sodium benzoate did not cause Ala40Thr (GCG→ACG) in superoxide dismutase gene. Sodium benzoate had the mutagenic and cytotoxic toxicity in lymphocytes caused by micronucleus formation and chromosome break[1].

体内活性: Sodium benzoate (NaB)?-treated rats spent less time in the open arm and had fewer entrances to the open arms in comparison with the control group (p<0.04). Also, the performance of the NaB-treated rats in fixed and accelerating speed rotarods was impaired, and the riding time (endurance) was lower than the control group (p<0.01)[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 3.85 mg/mL (26.69 mM)
H2O : 28 mg/mL (194.31 mM)


关键字: Benzoic acid sodium | Sodium benzoate | Sodium Benzoate

相关库: FDA-Approved Drug Library | Drug Repurposing Compound Library | Approved Drug Library | Inactive Ingredient Library | Clinical Compound Library | Bioactive Compounds Library Max | Human Metabolite Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途