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其他生物化学试剂

索利那新 T8147

英文名称:Solifenacin
品牌 厂商性质 产地 货期
TargetMol 生产商 美国 现货

性能特点

生化试剂,可用于动物细胞实验

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产品参数
规格 CAS号 价格 操作
50 mg 242478-37-1 ¥913.00 询底价
10 mg 242478-37-1 ¥393.00 询底价
1 mL 242478-37-1 ¥323.00 询底价
100 mg 242478-37-1 ¥1,430.00 询底价
5 mg 242478-37-1 ¥255.00 询底价
500 mg 242478-37-1 ¥3,560.00 询底价
200 mg 242478-37-1 ¥2,130.00 询底价
25 mg 242478-37-1 ¥622.00 询底价
产品介绍

Product Introduction
Bioactivity


英文名: Solifenacin

描述: Solifenacin (YM905 free base) 是一种新型的毒蕈碱受体拮抗剂,对 M1、M2和 M3受体的 pKi 值分别为 7.6、6.9 和 8.0。

体内活性: The inhibitory effects of Solifenacin on salivary and cardiac responses are only slight at 630 nmol/kg (0.3 mg/kg), and reach 66% and 49%, respectively, at 2100 nmol/kg (1 mg/kg). Solifenacin slightly increases saliva secretion at doses of 63 and 210 nmol/kg (0.03 and 0.1 mg/kg). However, Solifenacin reduces bladder responses by 40% at a dose of 210 nmol/kg (0.1 mg/kg) and abolishes them at 2100 nmol/kg (1 mg/kg). Solifenacin (0.01 to 0.3 mg/kg i.v.) dose-dependently increases bladder capacity and voided volume at doses of 0.03 mg/kg i.v. or more, but does not affect residual volume or micturition pressure at any dose tested.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 49 mg/mL (135.18 mM)
H2O : < 0.1 mg/mL (insoluble)


关键字: Muscarinic acetylcholine receptor | Solifenacin | YM905 | mAChR | YM 905 | Inhibitor | inhibit | YM-905

相关产品: 3-Epioleanolic acid | Anethole trithione | Epiberberine chloride | LY2119620 | Nitenpyram | Umeclidinium bromide | Darenzepine | VU0357017 hydrochloride | Bambuterol hydrochloride | Clidinium bromide

相关库: FDA-Approved Drug Library | Drug Repurposing Compound Library | Anti-Neurodegenerative Disease Compound Library | Approved Drug Library | Anti-Parkinson's Disease Compound Library | FDA-Approved & Pharmacopeia Drug Library | Drug-induced Liver Injury (DILI) Compound Library | Membrane Protein-targeted Compound Library | Inhibitor Library | Anti-Alzheimer's Disease Compound Library

索利那新 T8147信息由TargetMol中国为您提供,如您想了解更多关于索利那新 T8147报价、型号、参数等信息,欢迎来电或留言咨询。

注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途

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