盐酸多巴酚丁胺 T8149

Product Introduction
Bioactivity


英文名: Dobutamine hydrochloride

描述: Dobutamine hydrochloride (Dobutamine(hydrochloride)) 是一种合成的儿茶酚胺，可作用于肾上腺素能受体α1-AR、β1-AR 和β2-AR，是一种选择性的 β1-AR 受体激动剂，对 α1-AR 和 β2-AR 作用相对较弱。它能够增加心输出量，矫正低灌注。

动物实验: Animal Model:Tgαq*44 mice (heart failure models). Dosage:0.15 mg/kg, 0.5 mg/kg as a low dose, 1.5 mg/kg, 5 mg/kg, 20 mg/kg as a high dose. Administration:Intraperitoneal injection

体内活性: In wildtype mice increasing doses of dobutamine resulted in subsequent increase in the left ventricular function and heart rate acceleration, but significant inotropic, lusitropic, and chronotropic cardiac response was observed only after high doses of dobutamine.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 20 mg/mL (59.20 mM)
DMSO : 33 mg/mL (97.68 mM)


关键字: Dobutamine | drug | Adrenergic Receptor | Dobutamine hydrochloride | heart failure | Inhibitor | inhibit | sympathomimetic | shock | Beta Receptor | cardiogenic | Dobutamine Hydrochloride

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相关库: FDA-Approved Drug Library | Drug Repurposing Compound Library | Anti-Neurodegenerative Disease Compound Library | Approved Drug Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | GPCR Compound Library | Anti-Cancer Approved Drug Library | Anti-Alzheimer's Disease Compound Library

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