化合物Avacopan T8223
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
2 mg | 1346623-17-3 | ¥627.00 | 询底价 |
1 mL | 1346623-17-3 | ¥1,190.00 | 询底价 |
5 mg | 1346623-17-3 | ¥987.00 | 询底价 |
50 mg | 1346623-17-3 | ¥4,690.00 | 询底价 |
25 mg | 1346623-17-3 | ¥3,280.00 | 询底价 |
10 mg | 1346623-17-3 | ¥1,630.00 | 询底价 |
1 mg | 1346623-17-3 | ¥429.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Avacopan
描述: Avacopan (CCX168) 是一种口服小分子 C5aR (IC50: 0.1 nM.) 拮抗剂,可阻断 C5a 的作用并防止 AAV 小鼠模型中抗髓过氧化物酶抗体诱导的 GN 发展。
体内活性: CCX168 (avacopan), an orally administered selective and potent C5aR inhibitor.?CCX168 blocked the C5a binding, C5a-mediated migration, calcium mobilization, and CD11b upregulation in U937 cells as well as in freshly isolated human neutrophils.?CCX168 retains high potency when present in human blood.?A transgenic human C5aR knock-in mouse model allowed comparison of the in vitro and in vivo efficacy of the molecule.?CCX168 effectively blocked migration in in vitro and ex vivo chemotaxis assays, and it blocked the C5a-mediated neutrophil vascular endothelial margination.?CCX168 was effective in migration and neutrophil margination assays in cynomolgus monkeys[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 10 mg/mL (17.19 mM)
关键字: Avacopan | CCX-168 | CCX 168
相关产品: LEP(116-130)(mouse)TFA(258276-95-8 free base) | C5a Anaphylatoxin (human) | BCX 1470 hydrochloride | Iptacopan hydrochloride | Dexamethasone | Complement C5-IN-1 | ADH-503 | Eculizumab | CP-447697 | Zilucoplan TFA
相关库: Approved Drug Library | ReFRAME Related Library | Pediatric Drug Library | Orally Active Compound Library | NO PAINS Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途