化合物Mitochonic acid 5 T8366

Product Introduction
Bioactivity


英文名: Mitochonic acid 5

描述: Mitochonic acid 5 (MA-5) 能够调节线粒体 ATP 合成，可与线粒体结合，并改善肾小管和心肌细胞损伤。

细胞实验: TNFα was used to induce inflammatory injury in mouse microglial BV-2 cells with and without prior MA-5 treatment. Cellular apoptosis was assessed using the MTT and TUNEL assays. Mitochondrial functions were evaluated via mitochondrial membrane potential JC-1 staining, ROS flow cytometry analysis, mPTP opening assessment, and immunofluorescence of cyt-c. Mitophagy was examined using western blots and immunofluorescence. The pathways analysis was carried out using western blots and immunofluorescence with a pathway blocker[1].

体外活性: Treatment with MA-5 reduced mitochondrial apoptosis via upregulation of mitophagy.?Increased mitophagy degraded damaged mitochondria, disrupting mitochondrial apoptosis, neutralizing ROS overproduction, and improving cellular energy production.?We also identified that MA-5 regulated mitophagy via Bnip3 through the MAPK-ERK-Yap signaling pathway.?Inhibiting this signaling pathway or knocking down Bnip3 expression prevented MA-5 from having beneficial effects on mitochondrial homeostasis and increased microglial apoptosis[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 95 mg/mL (288.49 mM)


关键字: Mitochonic acid 5 | Inhibitor | MA 5 | Mitochonic acid5 | Mitochonic acid-5 | Mitochondrial Metabolism | MA5 | inhibit

相关产品: Genistein 8-c-glucoside | FGIN-1-43 | MSDC 0160 | Mito-TEMPO | α-Lipoic Acid | Olesoxime | Speract | CCCP | (-)-Epigallocatechin Gallate | ND-011992

相关库: Anti-Aging Compound Library | HIF-1 Signaling Pathway Compound Library | Mitochondria-Targeted Compound Library | Anti-Metabolism Disease Compound Library | Bioactive Compounds Library Max | Metabolism Compound Library | Cuproptosis Compound Library | Stem Cell Differentiation Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途