阿莫地喹 T8381

Product Introduction
Bioactivity


英文名: Amodiaquine

描述: Amodiaquine 是一种合成的4-氨基喹啉类抗疟剂，是一种有口服活性的组胺 N-甲基转移酶抑制剂。它也是一种Nurr1激动剂，有抗炎活性，可特异性结合Nurr1的配体结合域，EC50约为20 μM。

体外活性: Inflammatory responses are considered to play pivotal roles in the pathogenesis of intracerebral hemorrhage (ICH).?a nuclear receptor Nurr1 (NR4A2) was expressed prominently in microglia/macrophages and astrocytes in the perihematomal region in the striatum of mice after ICH.?Daily administration of a Nurr1 agonist amodiaquine (40 mg/kg, i.p.) from 3 h after ICH induction diminished perihematomal activation of microglia/macrophages and astrocytes.?Amodiaquine also suppressed ICH-induced mRNA expression of IL-1β, CCL2 and CXCL2, and ameliorated motor dysfunction of mice.?These results suggest that Nurr1 serves a novel target for ICH therapy.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 71 mg/mL (199.52 mM)


关键字: CCL2 | Nurr1 | IL-1β | Histone Methyltransferase | Amodiaquin | inhibit | Inhibitor | anti-inflammatory | CXCL2 | neuroprotective | Parasite | Amodiaquine | antimalarial | N-methyltransferase

相关产品: EPZ032597 | CM-579 | EZM0414 | DW14800 | BVT948 | UNC6934 | GSK591 | Tanshindiol C | PRMT4-IN-1 | EZH2-IN-2

相关库: FDA-Approved Drug Library | Drug Repurposing Compound Library | FDA-Approved & Pharmacopeia Drug Library | Inhibitor Library | Anti-Parasitic Compound Library | Orally Active Compound Library | Reprogramming Compound Library | Methylation Compound Library | Histone Modification Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途