盐酸卡利拉嗪 T8382

Product Introduction
Bioactivity


英文名: Cariprazine hydrochloride

描述: Cariprazine hydrochloride (RGH188 hydrochloride) 是一种抗精神病药物，是一种 D3 和 D2 受体部分激动剂，Ki 分别为 0.09 nM 和 0.5 nM，对5-HT(1A)受体有一定亲和力。

动物实验: Three monkeys using the following PET radioligands: [(11)C]MNPA (an agonist at D(2) and D(3) receptors), [(11)C]raclopride (an antagonist at D(2) and D(3) receptors), and [(11)C]WAY-100635 (an antagonist at 5-HT(1A) receptors). During each experimental day, the first PET measurement was a baseline study, the second after a low dose of cariprazine, and the third after the administration of a high dose[1].

体内活性: Cariprazine occupied D(2)/D(3) receptors in a dose-dependent and saturable manner, with the lowest dose occupying ~5% of receptors and the highest dose showing more than 90% occupancy. 5-HT(1A) receptor occupancy was considerably lower compared with D(2)/D(3) occupancy at the same doses, with a maximal value of ~30% for the raphe nuclei[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : < 1mg/ml (insoluble）


关键字: Dopamine Receptor | RGH-188 Hydrochloride | Cariprazine | 5-hydroxytryptamine Receptor | RGH188 | Cariprazine Hydrochloride | Inhibitor | 5-HT Receptor | RGH-188 | Serotonin Receptor | RGH 188 Hydrochloride | Cariprazine hydrochloride | RGH 188 | inhibit | RGH188 Hydrochloride

相关产品: AHN 1-055 hydrochloride | 6-Chloromelatonin | Desipramine hydrochloride | Lensiprazine | Abaperidone | FAUC 346 | Pentiapine | Chlorprothixene | Propionylpromazine hydrochloride | Fenoldopam mesylate

相关库: Anti-Neurodegenerative Disease Compound Library | Drug Repurposing Compound Library | Approved Drug Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | GPCR Compound Library | Anti-Cancer Approved Drug Library | EMA Approved Drug Library

盐酸卡利拉嗪 T8382信息由TargetMol中国为您提供，如您想了解更多关于盐酸卡利拉嗪 T8382报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途