帕米膦酸 T8400

Product Introduction
Bioactivity


英文名: Pamidronic acid

描述: Pamidronic acid 可用于各种骨吸收类疾病的研究。

细胞实验: Primary human BMMSCs were isolated from the mandible and marrow tissue. A proliferation assay was performed to determine the experimental concentration of pamidronate disodium. Alkaline phosphatase (ALP) activity, ALP staining, and Alizarin red S (ARS) staining were assessed after treatment with pamidronate disodium (0, 0.1, 0.5, 1, 5, 10 μg/mL). Quantitative real-time polymerase chain reaction and western blotting specific for Wnt and β-catenin signaling genes or proteins were performed after treatment with pamidronate disodium 0.5 μg/mL. Wnt3a was used to observe the osteogenic differentiation of BMMSCs during treatment with pamidronate disodium 0.5 μg/mL[1].

体外活性: Pamidronate disodium inhibited Wnt and β-catenin signaling, which controls osteogenic differentiation in BMMSCs. Wnt3a, a Wnt and β-catenin signaling activator, reversed the negative effects caused by pamidronate disodium to salvage the osteogenic defect in BMMSCs[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 6 mg/mL (25.52 mM)


关键字: inhibit | Inhibitor | β-catenin | Beta catenin | Wnt | Pamidronic acid

相关产品: Wogonin | Excisanin A | GSK-3β inhibitor 8 | β-catenin-IN-2 | DK419 | Gliotoxin | Ergosterol peroxide | Triptonide | MN-64 | NRX-252114

相关库: Anti-Aging Compound Library | Drug Repurposing Compound Library | Anti-Prostate Cancer Compound Library | Anti-Cancer Drug Library | Clinical Compound Library | Neuronal Differentiation Compound Library | Osteogenesis Compound Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Approved Drug Library | Anti-Cancer Active Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途