化合物LASSBio-1135 T8440

Product Introduction
Bioactivity


英文名: LASSBio-1135

描述: LASSBio-1135 是一种口服有效的 TRPV1 拮抗剂和 TNF-α 生成抑制剂。

体内活性: Oral administration of 100 mol x Kg(-1) LASSBio-1135 markedly reduced thermal hyperalgesia induced by carrageenan, however at 10 mol x Kg(-1) only a partial reduction was observed at the 4th h. Neutrophil recruitment and TNF-α production after carrageenan stimulus was also inhibited by the treatment with LASSBio-1135.?Modulating TRPV1 and TNF-α production, two key therapeutic targets of neuropathic pain, 100 mol x Kg(-1) LASSBio-1135 was orally efficacious in reversing thermal hyperalgesia and mechanical allodynia produced by partial sciatic ligation 7-11 days after surgery without provoking hyperthermia, a common side effect of TRPV1 antagonists.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 2.87 mg/mL (10.01 mM)


关键字: LASSBio 1135 | LASSBio-1135 | LASSBio1135

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相关库: Pyroptosis Compound Library | Angiogenesis related Compound Library | Cytokine Inhibitor Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Inhibitor Library | Anti-Fibrosis Compound Library | Apoptosis Compound Library | Orally Active Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途