化合物M8-B Hydrochloride T8442

Product Introduction
Bioactivity


英文名: M8-B Hydrochloride

描述: M8-B Hydrochloride 是一种选择性瞬时受体电位 melastatin-8 (TRPM8) 通道拮抗剂。

动物实验: Eight day old male Wistar rat pups were used for induction of febrile seizure.?M8 B and diazepam were injected intraperitoneally.?The rat pups were then transferred to a heated plexiglas chamber and the latency to the first febrile seizure was measured.?In addition, different groups of mice were pretreated with M8 B and received a convulsant dose of pentylenetetrazol (PTZ).?Latencies to stages 2 and 4 and duration of stage 5 seizure episodes were measured.The effect of M8 B on electroshock induced seizures was also investigated and hindlimb extension time was measured[1].

体内活性: M8 B, a TRPM8 antagonist, can reduce body temperature.M8 B decreased the body temperature of rat pups and increased the latency to the first febrile seizure, implying a significant protective effect.?It also induced a significant anticonvulsant effect in PTZ but not electroshock induced convulsions.?M8 B showed anticonvulsant effects in both febrile and PTZ induced seizures.?M8 B had a hypothermic effect with significant protective effects on febrile and PTZ induced seizures.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 27.5 mg/mL (63.52 mM)


关键字: M8 B Hydrochloride | M8-B Hydrochloride | M-8-B Hydrochloride | M8B Hydrochloride

相关产品: JYL 1421 | (Z)-Capsaicin | RN-1665 | AM-0902 | (+)-Camphor | Dihydrocapsaicin | GSK3395879 | Imperatorin | TRPV3 antagonist 74a | Englerin A

相关库: Ion Channel Inhibitor Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途