化合物SX-682 T8497

Product Introduction
Bioactivity


英文名: SX-682

描述: SX-682 是口服有效的 CXCR1和 CXCR2变构抑制剂，可以阻断肿瘤髓系抑制细胞募集并增强 T 细胞活化和抗肿瘤免疫，具有治疗去势抵抗性前列腺癌的潜力。

体外活性: SX-682 significantly inhibited trafficking of PMN-MDSCs without altering CXCR2 ligand expression.?Trafficking of CXCR1+ macrophages was unaltered, possibly due to coexpression of CSF1R.?Reduced PMN-MDSC tumor infiltration correlated with enhanced accumulation of endogenous or adoptively transferred T cells.?Accordingly, tumor growth inhibition or the rate of established tumor rejection following programed death-axis (PD-axis) immune checkpoint blockade or adoptive cell transfer of engineered T cells was enhanced in combination with SX-682.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 250 mg/mL (535.10 mM)


关键字: cells | allosteric | recruitment | suppressor | Inhibitor | tumor | CXCR | CXC chemokine receptors | immunity | SX-682 | MDSCs | inhibit | myeloid-derived | SX682 | SX 682 | antitumor

相关产品: Tannic acid | ATI-2341 | Ulocuplumab | MSX-130 | Ac-Pro-Gly-Pro-OH | SRT3109 | SB225002 | Balixafortide | CXCR4-IN-1 | Artemotil

相关库: Drug Repurposing Compound Library | Anti-Cancer Drug Library | Immuno-Oncology Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Inhibitor Library | GPCR Compound Library | Anti-Cancer Active Compound Library | Covalent Inhibitor Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途