化合物IM156 T8532

Product Introduction
Bioactivity


英文名: IM156

描述: IM156 (HL156A; HL271 acetate) 是衍生自二甲双胍的化合物，是一种强效的，具有口服活性的AMPK 激活剂。IM156 在动物模型中可缓解与年龄相关的认知下降。IM156 是一种有效的氧化磷酸化 (OXPHOS) 抑制剂，可用于实体肿瘤的研究。

体外活性: IM156 (0.31-10 μM) phosphorylates AMPKα1 Thr172 in NIH3T3 mouse fibroblast cells in a dose- and time-dependent manner [1]. IM156 does not affect the expression of key factors involved in glucose homeostasis like glucose-6-phosphatase (G6pase) or phosphoenolpyruvate carboxykinase 1 (Pck1) [1]. Western Blot Analysis [1] Cell Line: NIH3T3 cells Concentration: 0.31 μM, 0.62 μM, 1.25 μM, 2.5 μM, 5 μM, 10 μM Incubation Time: 4 hours Result: Significantly increased the AMPK phosphorylation rate.

体内活性: IM156 does not affect metabolic regulation assessed by body weight, blood glucose, insulin levels and lipid metabolite content in mice with diet-induced obesity [1]. IM156 (50 mg/kg; for 2 months) does not affect body weight, general locomotion, or anxiety [2]. IM156 markedly attenuates the aging-induced decline in novel object recognition memory and spatial working memory [2]. IM156 markedly increases AMPK activation in the hippocampus of aged mice [2]. Animal Model: C57BL/6J mice (young group/12-16 weeks, old groups/20-22 months) [2] Dosage: 50 mg/kg Administration: Oral administration (drinking water), for 2 months Result: Attenuated age-related cognitive decline.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 27.5 mg/mL (87.22 mM)


关键字: IM 156 | IM156 | IM-156

相关产品: Mito-LND | BAM 15 | VLX600 | DX3-213B | Acetyl Coenzyme A trisodium

相关库: Glutamine Metabolism Compound Library | Bioactive Compounds Library Max | Anti-Lung Cancer Compound Library | Inhibitor Library | Anti-Cancer Active Compound Library | Apoptosis Compound Library | Hematonosis Compound Library | Orally Active Compound Library | Preclinical Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途