化合物FEN1 Inhibitor C2 T8545

Product Introduction
Bioactivity


英文名: FEN1-IN-4

描述: FEN1-IN-4 (FEN1 Inhibitor C2) 是人类皮瓣内切核酸酶-1 (hFEN1) 抑制剂。

体外活性: FEN1 Inhibitor C2 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a, both frequently mutated in colorectal cancers.?FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of MMS (methyl methanesulfonate)-induced alkylation damage, and its knockdown or inhibition increases sensitivity to TMZ (temozolomide) in glioblastoma and colorectal cancer cell lines.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 100 mg/mL (430.59 mM)


关键字: flap | colorectal | Inhibitor | endonuclease | FEN1IN4 | cells | colon | cancer | FEN1-IN-4 | inhibit | FEN-1-IN-4 | glioblastoma | FEN1 IN 4 | human | hFEN1

相关库: Bioactive Compounds Library Max | Inhibitor Library | DNA Damage & Repair Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途