化合物CAL-101 T8651

Product Introduction
Bioactivity


英文名: CAL-101

描述: CAL-101 (Idelalisib) 是 p110δ 的选择性抑制剂（IC50：2.5 nM；在无细胞试验中）；显示对 p110δ 的选择性比 p110α/β/γ 高 40 到 300 倍，对 p110δ 的选择性比 C2β、hVPS34、DNA-PK 和 mTOR 高 400 到 4000 倍。

体外活性: CAL-101 blocked constitutive phosphatidylinositol-3-kinase signaling, resulting in decreased phosphorylation of Akt and other downstream effectors, an increase in poly(ADP-ribose) polymerase and caspase cleavage and an induction of apoptosis[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 25 mg/mL (60.18 mM)


关键字: CAL101 | CAL 101 | GS1101 | GS 1101 | CAL-101

相关产品: Linperlisib | AZD-8835 | SAR405 | CH5132799 | PKI-402 | Gedatolisib | Monomethyl lithospermate | PI3K-IN-1 | Sennidin A | Buparlisib

相关库: Drug Repurposing Compound Library | FDA-Approved Kinase Inhibitor Library | Targeted Therapy Drug Library | Anti-Cancer Drug Library | Anti-Ovarian Cancer Compound Library | Inhibitor Library | Kinase Inhibitor Library | Anti-Cancer Active Compound Library | Anti-Cancer Approved Drug Library | Glycolysis Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途