化合物KRAS inhibitor-9 T8756

Product Introduction
Bioactivity


英文名: KRAS inhibitor-9

描述: KRAS inhibitor-9 (DUN09716) 是一种 KRAS 抑制剂，阻止 GTP-KRAS 的形成和 KRAS 下游激活。它以中等的结合亲和力与 KRAS G12D、KRAS G12C 和 KRAS Q61H 蛋白结合，选择性抑制具有 KRAS 突变的 NSC-LC 细胞的增殖。它可导致 G2/M 细胞周期停滞并诱导凋亡。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 230 mg/mL (785.49 mM)


关键字: non-small | proliferation | inhibit | KRAS inhibitor 9 | KRAS inhibitor9 | DUN-09716 | cytotoxicity | Apoptosis | cell | H460 | mutant | H2122 | H358 | lung | Inhibitor | Ras | cancer | cells | DUN 09716 | KRAS inhibitor-9 | GTP-KRAS

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相关库: HIF-1 Signaling Pathway Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | GPCR Compound Library | Inhibitor Library | Kinase Inhibitor Library | Anti-Colorectal Cancer Compound Library | Reprogramming Compound Library | NO PAINS Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途