化合物JBJ-04-125-02 T8872
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mg | 2140807-05-0 | ¥3,660.00 | 询底价 |
1 mg | 2140807-05-0 | ¥847.00 | 询底价 |
25 mg | 2140807-05-0 | ¥5,890.00 | 询底价 |
1 mL | 2140807-05-0 | ¥2,730.00 | 询底价 |
100 mg | 2140807-05-0 | ¥10,800.00 | 询底价 |
5 mg | 2140807-05-0 | ¥2,280.00 | 询底价 |
50 mg | 2140807-05-0 | ¥8,190.00 | 询底价 |
Product Introduction
Bioactivity
英文名: (Rac)-JBJ-04-125-02
描述: (Rac)-JBJ-04-125-02 (JBJ-04-125-02) 是 JBJ-04-125-02 的消旋体,是选择性突变,可口服的 EGFR 变构抑制剂,对EGFRL858R/T790M 的IC50为 0.26 nM。
动物实验: Ba/F3, H1975, H3255GR and H3255DR cells were treated with increasing concentrations of inhibitors for 72 hours and growth or the inhibition of growth was assessed by MTS assay according to previously established methods.
体外活性: (Rac)-JBJ-04-125-02 is the racemate of JBJ-04-125-02. JBJ-04-125-02 is a potent, mutant-selective, allosteric and orally active EGFR inhibitor with an IC50 of 0.26 nM for EGFRL858R/T790M[1].
体内活性: The combination of osimertinib and JBJ-04-125-02 is a significantly more effective treatment approach than either agent alone[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 55 mg/mL (101.17 mM)
关键字: Allosteric | anti-proliferation | HER1 | inhibit | ErbB-1 | (Rac)JBJ0412502 | Inhibitor | racemate | Epidermal growth factor receptor | anti-tumor | (Rac) JBJ 04 125 02 | EGFR | T790M-mutant
相关产品: EAI001 | Icotinib | AV-412 free base | EGFR-IN-85 | Pelitinib | AEE788 | PAT-505 | Tucatinib | Inetetamab | EGFR-IN-2
相关库: JAK-STAT Compound Library | Anti-Liver Cancer Compound Library | Cytokine Inhibitor Library | Membrane Protein-targeted Compound Library | Kinase Inhibitor Library | Inhibitor Library | Anti-Cancer Active Compound Library | Tyrosine Kinase Inhibitor Library | Orally Active Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途