化合物Bemnifosbuvir hemisulfate T9331

Product Introduction
Bioactivity


英文名: Bemnifosbuvir hemisulfate

描述: Bemnifosbuvir hemisulfate (AT-527) 是一种 HCV 病毒复制抑制剂。

体外活性: The potent in vitro activity of AT-511, the free base of bemnifosbuvir hemisulfate, against several coronaviruses, including SARS-CoV-2. In normal human airway epithelial cells, the concentration of AT-511 required to inhibit replication of SARS-CoV-2 by 90% (EC90) was 0.47?μM, very similar to its EC90 against human coronavirus (HCoV)-229E, HCoV-OC43, and SARS-CoV in Huh-7 cells[1].

体内活性: When given orally to rats and monkeys, bemnifosbuvir hemisulfate preferentially delivered high levels of AT-9010 in the liver in vivo.These favorable preclinical attributes support bemnifosbuvir hemisulfate may increase SVR rates[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 170 mg/mL (269.60 mM)


关键字: Inhibitor | antiviral | phosphoramidate | HCV | nucleotide | Bemnifosbuvir | SARS-CoV | pangenotypic | Bemnifosbuvir hemisulfate | AT 527 | Bemnifosbuvir Hemisulfate | guanosine | SARS coronavirus | AT527 | Hepatitis C virus | inhibit

相关产品: Honokiol | PSI-352938 | Ladanein | GS-9256 | Maribavir | BMS-929075 | Saikosaponin B2 | PSI-6206 | Velpatasvir | BLT-1

相关库: Nucleotide Compound Library | Drug Repurposing Compound Library | Clinical Compound Library | Orally Active Compound Library | NO PAINS Compound Library | Covalent Inhibitor Library | Anti-Infection Compound Library

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