化合物CHIKV-IN-2 T9394

Product Introduction
Bioactivity


英文名: CHIKV-IN-2

描述: CHIKV-IN-2 基孔肯雅病毒的选择性抑制剂，具有强大的细胞抗病毒活性 (EC90=270 nM) 以及能够改善肝微粒体稳定性。它能够抑制细胞靶二氢乳清酸脱氢酶的活性。

体外活性: CHIKV-IN-2 is active against alphavirus VEEV (EC90=0.40 μM) as well as flaviviruses such as West Nile Virus (WNV, EC90=0.20 μM) and Dengue Virus Strain-2 (DENV-2, EC90=0.60 μM)[1]. CHIKV-IN-2 is a potent pan-alphavirus inhibitor, with EC90s of 0.85-2.5 μM for CHIKV clinical isolates and attenuated vaccine strains[1].

体内活性: CHIKV-IN-2 (40 mg/kg; p.o., i.p., s.c.) exhibits moderate bioavailability (F=41%, 43%, 4%), terminal elimination half-life (t1/2=9.9, 18.5, 18.6 h) and Cmax (642, 858, 90 ng/mL) in mice[1]. CHIKV-IN-2 (80 mg/kg; i.p. twice a day for 3 days) significantly decreases infectious CHIKV dissemination to other tissues of mice[1]. CHIKV-IN-2 (1 mg/kg; i.v.) exhibits terminal elimination half-life (t1/2= 2.02 h) and AUC (497 h?ng/mL) in mice[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 99 mg/mL (273.13 mM)


关键字: Dihydroorotate Dehydrogenase | CHIKV | DHODH | CHIKV-IN-2 | virus | inhibit | CHIKV IN 2 | Chikungunya | Inhibitor | CHIKVIN2

相关产品: DHODH-IN-4 | Orotic acid | Brequinar | Trilostane | Ethionamide | Etamicastat hydrochloride | AGI-14100 | (E/Z)-Teriflunomide | 18β-Glycyrrhetinic acid | alpha-Mangostin

相关库: Anti-Cancer Metabolism Compound Library | Mitochondria-Targeted Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Metabolism Compound Library | Anti-Viral Compound Library | NO PAINS Compound Library | Anti-Infection Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途