Inarigivir铵 T9518

Product Introduction
Bioactivity


英文名: Inarigivir ammonium

描述: Inarigivir ammonium (SB-9200 ammonium) 是一种二核苷酸抗病毒化合物，可显着降低表达乙型肝炎病毒的转基因小鼠的 HBV DNA。它是一种激活细胞内先天免疫的视黄酸诱导基因-I 激动剂。

体外活性: Inarigivir is active against HBV variants carrying resistance markers against all the nucleos(t)ide analogues approved for treating chronic hepatitis B[1].

体内活性: Administration of 100 mg/kg/day Inarigivir (ip) significantly reduces viral DNA in the liver and shows anti-HBV activity while serum HBV DNA is not reduced. Inarigivir does not affect levels of HBV RNA in liver, levels of HBeAg in serum, or mean titers of HBsAg. The minimal effective dose is identified to be between 1.6 and 0.5 mg/kg/day using liver HBV DNA values[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 98 mg/mL (162.11 mM)


关键字: SB-9000 | HBV | ORI9020 | HCV | Hepatitis B virus | ORI 9020 | antiviral | inhibit | Inarigivir | Inhibitor | ORI-9020 | RIG-I | SB9000 | SB 9000 | Huh7 | Inarigivir ammonium

相关产品: Punicalagin | Etidronic acid | Oxethazaine | Neochlorogenic acid methyl ester | Entecavir monohydrate | Bulevirtide (Myrcludex B) acetate | Kurarinol | Dihydrodehydrodiconiferyl alcohol 9-O-α-L-rhamnopyranoside | Bifendate | Telbivudine

相关库: Nucleotide Compound Library | Bioactive Compounds Library Max | Orally Active Compound Library | Anti-Viral Compound Library | Anti-Infection Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途