化合物NS3861 T9542
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
5 mg | 216853-59-7 | ¥383.00 | 询底价 |
1 mg | 216853-59-7 | ¥178.00 | 询底价 |
10 mg | 216853-59-7 | ¥713.00 | 询底价 |
500 mg | 216853-59-7 | ¥9,180.00 | 询底价 |
50 mg | 216853-59-7 | ¥2,860.00 | 询底价 |
25 mg | 216853-59-7 | ¥1,690.00 | 询底价 |
1 mL | 216853-59-7 | ¥397.00 | 询底价 |
100 mg | 216853-59-7 | ¥4,230.00 | 询底价 |
Product Introduction
Bioactivity
英文名: NS3861
描述: NS3861 是烟碱型乙酰胆碱受体的激动剂,对α3β4 nAChR 具有高亲和力。能够分别与α3β4 (Ki:0.62 nM)、α3β2 (Ki:25 nM)、α4β4 (Ki:7.8 nM)、α4β2 (Ki:55 nM) 结合。
体外活性: NS3861 was found to activate wild-type α3β4 nAChRs (Figs. 3R and 4) but did not activate wild-type α4β2. Whereas NS3861 was a partial agonist at α3β4, it proved to be a full agonist at α3β2 albeit with ~10-fold lower potency consistent with the binding affinities. Efficacy at the α3/α4 + β4/β2 receptor was almost identical to that of wild-type α3β4, whereas no efficacy could be seen at α4/α3 + β2/β4[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 100 mg/mL (351.84 mM)
关键字: α3β4 nAChR | inhibit | Inhibitor | Heteromeric | Patch Clamp | Nicotinic acetylcholine receptors | nAChR | Pharmacology | NS-3861 | NS3861 | NS 3861
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相关库: Anti-Neurodegenerative Disease Compound Library | Neurotransmitter Receptor Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途