化合物Tepotinib hydrochloride(1 : x) T9601

Product Introduction
Bioactivity


英文名: Tepotinib hydrochloride(1 : x)

描述: Tepotinib hydrochloride(1 : x) 是一种口服生物可利用的间充质-上皮转化 (MET) TKI，主要针对具有 METex14 跳跃突变的特定 NSCLC 患者开发。

体外活性: Tepotinib hydrochloride(1 : x) potently inhibits ABCB1 and ABCG2 efflux transporters, which was confirmed by molecular docking. In addition, Tepotinib hydrochloride(1 : x) inhibited several recombinant cytochrome P450 (CYP) isoforms with varying potency. Tepotinib hydrochloride(1 : x) synergistically reversed daunorubicin and mitoxantrone resistance in cells with ABCB1 and ABCG2 overexpression, respectively[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (94.51 mM)


关键字: Tepotinib hydrochloride(1 : x)

相关产品: Altiratinib | MET/PDGFRA-IN-2 | Glesatinib | Tyrosine kinase-IN-6 | CEP-40783 | AMG-208 | JNJ-38877618 | X-376 | SGI-7079 | Emibetuzumab

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