环亮氨酸 T9626

Product Introduction
Bioactivity


英文名: Cycloleucine

描述: Cycloleucine 是 NMDA 受体相关甘氨酸受体的拮抗剂，Ki 为 600 μM。Cycloleucine 也是 S-腺苷甲硫氨酸介导的甲基化的竞争性抑制剂，具有抗焦虑和细胞抑制作用。

体外活性: Cytostatic (10 µg/mL) inhibits the viability of human KB and mouse L1210s leukemia cell lines. Cycloleucine (4-40 mM; 3 h) blocks internal methylation of viral RNA in B77 transformed chick embryo fibroblasts. Cycloleucine (40 mM; 24 h) blocks the formation of both m6A and the penultimate Gm in B77 38S RNA subunits by greater than 90%[2].

体内活性: Cycloleucine (0.5, 1.0, 2.0, 4 µg/µL; intracerebroventrically) increases time spent in open arms, open arm entries, and extreme arrivals in rats[3]. In Semliki Forest virus strain A7(74) infected and control mice, Cycloleucine reduces thymus and spleen weights[4].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 45 mg/mL (348.41 mM)
DMSO : < 1 mg/mL (insoluble or slightly soluble)


关键字: Ionotropic glutamate receptors | Cycloleucine | inhibit | glycine | NMDA | cytostatic | nucleic | Inhibitor | methylations | anxiolytic | transferase | iGluR | ATP

相关产品: CNS-5161 hydrochloride | Glypromate | 1-Aminocyclobutanecarboxylic acid | BDBM50597431 | NMDAR/TRPM4-IN-2 | PEAQX | Quinolinic acid | Rapastinel Trifluoroacetate | L-689560 | Co 101244 hydrochloride

相关库: Anti-Neurodegenerative Disease Compound Library | Neurotransmitter Receptor Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Antidepressant Compound Library | Human Metabolite Library | Inhibitor Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途