化合物NCT-58 T9996

Product Introduction
Bioactivity


英文名: NCT-58

描述: NCT-58是一种有效的C 端HSP90抑制剂。NCT-58不会引起热休克反应（HSR）。NCT-58通过同时下调HER 家族成员以及抑制Akt 磷酸化来激发抗肿瘤活性。NCT-58杀死对曲妥珠单抗耐药的乳腺癌干细胞样细胞。NCT-58诱导HER2阳性乳腺癌细胞凋亡。

体外活性: NCT-58 treatment (0.1-10 μM; 72 hours) increases the number of early and late apoptotic cells in HER2-positive BT474 and SKBR3 cells. NCT-58 treatment (0.1-20 μM; 72 hours) dose-dependently reduces cell viability in HER2-positive BT474 and SKBR3 cells. NCT-58 treatment (2-10 μM; 72 hours) effectively reduced the levels of truncated p95HER2 and its phosphorylated form, as well as downregulation of Akt and phospho-Akt (Ser473) protein contents in JIMT-1 and MDA-MB-453 cells [1].

体内活性: NCT-58（30 mg/kg；i.p.；每隔一天，共47天）显著抑制肿瘤生长，并显著减少肿瘤重量。NCT-58（30 mg/kg；i.p.；每隔一天，共47天）抑制Trastuzumab耐药性肿瘤生长[1]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 40 mg/mL (85. mM)


关键字: NCT 58 | NCT-58

相关产品: PU-H71 HCl | TRC051384 HCl | HSP90-IN-23 | VER49009 | Dihydroberberine | BIIB021 | KNK437 | 2',4'-DIHYDROXYCHALCONE | GRP78-IN-3 | YUM70

相关库: Anti-Breast Cancer Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Cytoskeletal Signaling Pathway Compound Library | Anti-Cancer Active Compound Library | Exosome Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途