2-乙酰苯甲酸 TMA0536

Product Introduction
Bioactivity


英文名: 2-Acetylbenzoic acid

描述: 2-Acetylbenzoic acid 在抑制血小板功能和血小板前列腺素 (PG) 合成方面比 2-丙酰氧基苯甲酸更有效，尽管这些药物在抑制前列环素 (PGI2) 合成方面的效力相当。

体外活性: A series of benzoic acid derivatives was tested for specificity of action on human platelet function and platelet prostaglandin (PG) synthesis versus prostacyclin (PGI2) production by rat and rabbit aorta rings. None of the agents tested was more specific for one system than the other. ASA was more potent than 2-propionyloxybenzoic acid (2-PBA) in inhibiting platelet function and platelet PG synthesis although the potencies of these agents were comparable in inhibiting PGI2 synthesis. 3-Propionyloxybenzoic acid (3-PBA) caused increased activity in both systems while 2-Acetylbenzoic acid had only minor effects. A cyclical derivative, 3-methylphthalide (3-MP), inhibited both platelet function and PGI2 synthesis although it did not inhibit cyclo-oxygenase activity, suggesting a novel mechanism of action[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 55 mg/mL (335.04 mM)


关键字: 2 Acetylbenzoic acid | 2-Acetylbenzoic acid | 2Acetylbenzoic acid

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相关库: Anti-Inflammatory Traditional Chinese Medicine Compound Library | Selected Plant-Sourced Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Natural Product Library for HTS | RO5 Drug-like Natural Product Library | Natural Product Library | Bioactive Compound Library

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