CD3 epsilon/CD3e, Cynomolgus, 重组蛋白 (aa 22-117, hFc) TMPJ-01259
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
50 μg | TMPJ-01259 | ¥2,480.00 | 询底价 |
1 mg | TMPJ-01259 | ¥17,400.00 | 询底价 |
10 μg | TMPJ-01259 | ¥820.00 | 询底价 |
500 μg | TMPJ-01259 | ¥12,100.00 | 询底价 |
Product Introduction
Bioactivity
英文名: CD3 epsilon/CD3e Protein, Cynomolgus, Recombinant (aa 22-117, hFc)
描述: T-cell surface glycoprotein CD3 epsilon chain, also known as CD3E, is a single-pass type I membrane protein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. The CD3 epsilon subunit of the T cell receptor (TCR) complex contains two defined signaling domains, a proline-rich sequence and an immune tyrosine activation motifs (ITAMs), and this complex undergoes a conformational change upon ligand binding that is thought to be important for the activation of T cells. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. Homozygous mutations in CD3D and CD3E genes lead to a complete block in T-cell development and thus to an early-onset severe combined immunodeficiency phenotype.
存储条件: Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6~12 month
关键字: CD3e molecule, epsilon | CD3e antigen, epsilon polypeptide | CD3-TCR complex | TiT3 complex | FLJ 18683 | FLJ-18683
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