茯苓新酸 B TN1031

Product Introduction
Bioactivity


英文名: Poricoic acid B

描述: Poricoic acid B 是提取自 Poria cocos 中，拥有抗肿瘤作用。

体外活性: These two, and eight other known compounds isolated from the sclerotium, Poricoic acid B (3), poricoic acid A (4), tumulosic acid (5), dehydrotumulosic acid (6), 3-epidehydrotumulosic acid (7), polyporenic acid C (8), 25-hydroxy-3-epidehydrotumulosic acid (9), and dehydroabietic acid methyl ester (10), showed potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Evaluation of the cytotoxicity of compounds 1 and 4 against human cancer cell lines revealed that 1 was significantly cytotoxic to leukemia HL-60 cells [GI(50) (concentration that yields 50% growth) value 39.3 nM], although it showed only moderate cytotoxicity to the other cells. Compound 4 exhibited moderate cytotoxicity to all of the cancer cell lines tested.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 22.5 mg/mL (46.42 mM)


关键字: Inhibitor | inhibit | Poricoic acid B

相关库: Anti-Cancer Compound Library | Selected Plant-Sourced Compound Library | Bioactive Compounds Library Max | Chinese Pharmacopoeia Natural Product Library | Traditional Chinese Medicine Monomer Library | Anti-Cancer Active Compound Library | Food as Medicine Compound Library | NO PAINS Compound Library | Bioactive Compound Library | Anti-infective Natural Product Library

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