番泻苷元A TN1033

Product Introduction
Bioactivity


英文名: Sennidin A

描述: Sennidin A 是从狭叶番泻分离得到的一种天然产物，能够抑制 HCV NS3 解旋酶，其 IC50值为0.8 μM。它诱导 Akt 和葡萄糖转运蛋白4的磷酸化，刺激葡萄糖掺入。

体外活性: Here, we exploited the avidity of the Sennidin A (SA) tracer and radioiodinated SA (131I-SA) to necrotic tumors in order to further empower TNT. We showed high uptake and prolonged retention of SA in necrotic tumors and a quick clearance in other non-targeted tissues including the liver. On SPECT-CT images, tumor mass appeared persistently as a hotspot. Based on the prominent targetability of 131I-SA to the tumor necrosis, we designed a combinational theragnostic modality. The vascular disrupting agent (VDA) combretastatin A4 phosphate (CA4P) was used to cause massive tumor necrosis, which formed the target of 131I-SA that subsequently killed the residual tumor cells by cross-fire irradiation of beta particles. Consequently, 131I-SA combined with CA4P significantly inhibited tumor growth, extended tumor doubling time and prolonged mean animal survival[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Hepatitis C virus | PKB | inhibit | Akt | Glucose transporter | Inhibitor | HCV | Protein kinase B | GLUT | Sennidin A

相关产品: Sofosbuvir impurity G | Daclatasvir dihydrochloride | Maribavir | SB-734117 | BMS-929075 | PSI-6206 | 2′-O-Methylcytidine | Paritaprevir | Isatoribine | Deferiprone

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途