没食子酰芍药苷 TN1067

Product Introduction
Bioactivity


英文名: Galloylpaeoniflorin

描述: Galloylpaeoniflorin (6'-O-Galloyl paeoniflorin) 是 NF-κB 抑制剂，同时也是 DNA 裂解抑制剂。

体外活性: This study is the first investigation of the cytoprotective effects of GPF against hydrogen peroxide (H2O2)-induced cell injury and death in human HaCaT keratinocytes. GPF demonstrated a significant scavenging capacity against the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical, H2O2-generated intracellular reactive oxygen species (ROS), the superoxide anion radical (O2 (-)), and the hydroxyl radical (?OH). GPF also safeguarded HaCaT keratinocytes against H2O2-provoked apoptotic cell death and attenuated oxidative macromolecular damage to DNA, lipids, and proteins. The compound exerted its cytoprotective actions in keratinocytes at least in part by decreasing the number of DNA strand breaks, the levels of 8-isoprostane (a stable end-product of lipid peroxidation), and the formation of carbonylated protein species[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (79.04 mM)


关键字: Galloylpaeoniflorin | Nuclear factor-kappaB | inhibit | Inhibitor | NF-κB | Nuclear factor-κB

相关产品: NF-κΒ activator 1 | (-)-Pinoresinol | DB1976 dihydrochloride | Dehydrodiisoeugenol | Sulfuretin | Celaphanol A | Licochalcone D | Isorhamnetin 3-O-galactoside | Asperulosidic acid | Heliangin

相关库: Anti-Breast Cancer Compound Library | Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library | Traditional Chinese Medicine Monomer Library | Cuproptosis Compound Library | Anti-Pancreatic Cancer Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途