麦冬皂苷 D' TN1071

Product Introduction
Bioactivity


英文名: Ophiopogonin D'

描述: Ophiopogonin D'可以以剂量依赖性方式激活 SIRT1。 Ophiopogonin D'也非竞争性地抑制 UGT1A6 和 UGT1A10。

体外活性: In vitro incubation system to model UGT reaction was used. Recombinant UGT isoforms-catalyzed 4-methylumbelliferone (4-MU) glucuronidation and UGT1A4-catalyzed trifluoperazine (TFP) glucuronidation reactions were employed to phenotype the inhibition profile of maidong's components towards the activity of UGT isoforms. Different inhibition potential of maidong's components towards various UGT isoforms was observed. Based on the inhibition kinetic investigation results, ophiopogonin D (OD) noncompetitively inhibited UGT1A6 and competitively inhibited UGT1A8, Ophiopogonin D' (OD') noncompetitively inhibited UGT1A6 and UGT1A10, and ruscorectal (RU) exhibited competitive inhibition towards UGT1A4. The inhibition kinetic parameters were calculated to be 20.6, 40.1, 5.3, 9.0, and 0.02 μM, respectively[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 8.55 mg/mL (10 mM)


关键字: Ophiopogonin D' | Sirtuin | inhibit | Inhibitor

相关产品: MIND4-19 | Sirtinol | CAY10602 | 4'-bromo-Resveratrol | WAY-323061 | Sirt2-IN-1 | SIRT1-IN-1 | SIRT2-IN-9 | Suramin Sodium Salt | Sirtuin-1 inhibitor 1

相关库: Anti-Aging Compound Library | Anti-Cancer Compound Library | Selected Plant-Sourced Compound Library | Bioactive Compounds Library Max | Traditional Chinese Medicine Monomer Library | Natural Product Library for HTS | Metabolism Compound Library | Histone Modification Compound Library | Bioactive Compound Library | Natural Product Library

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