蒲公英赛醇 TN1077

Product Introduction
Bioactivity


英文名: Taraxerol

描述: Taraxerol(Alnulin) 是从蒲公英中提取出来的具有抗炎和抗癌作用的化合物。Taraxerol 通过抑制 NF-κB 信号通路来减轻急性炎症，并诱导细胞凋亡 (apoptosis)。

体外活性: Taraxerol (0-100 μM; 24 or 48 hours) significantly reduced cell viability to 95% (20 μM), 89.8% (40 μM), 82.6% (60 μM), 72.9% (80 μM), and 63.6% (100 μM). The cell viability of this compound in Hela cells at 20 μM and 100 μM concentrations within 48 hours was 90.7% and 53.6%, respectively.[1]Taraxerol (80 μM; 24 or 48 hours) induces apoptosis and cell death in HeLa cells in a dose-dependent manner. Annexin V/PI double staining method showed that compared with the number of apoptotic cells in the control group at the early (6.5%) and late (0.5%) stages, Taraxerol could significantly induce cell apoptosis (24.2% in the early stage and 16.2% in the late stage).[1]

体内活性: Taraxerol (5及10 mg/kg; i.p.) 可以减少卡拉胶引起的爪肿胀。5mg/kg Taraxerol 的效果在卡拉胶处理后4小时显著（p<0.05）。[2]

存储条件: store at low temperature,keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : <0.1 mg/ml
THF : 5 mg/mL (11.72 mM)
H2O : <0.1 mg/ml


关键字: Taraxerol

相关产品: L-Cystathionine | ICCB-19 hydrochloride | 2'-Deoxy-2'-fluoro-beta-D-arabinoguanosine | ST1074 | icFSP1 | SLU-PP-1072 | AZD0156 | Tetrahydroxyquinone | Sophoraflavanone G | Hydroxyurea

相关库: Immunology/Inflammation Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途