去氧地胆草素 TN1079

Product Introduction
Bioactivity


英文名: Deoxyelephantopin

描述: Deoxyelephantopin 是来自Elephantopus scaber 的，具有生物活性的天然倍半萜烯内酯，能够抑制NF-κB，MAPK，PI3K/Akt 和β-catenin 信号传导。它可广泛用于癌症方面的研究。

体外活性: Deoxyelephantopin was evaluated for its effects on the expression of mRNAs encoding CYP1A2, CYP2D6 and CYP3A4, and protein expression and resultant enzymatic activity. The mRNA and protein expression of cytochrome isoforms were carried out using an optimized multiplex qRT-PCR assay and Western blot analysis, respectively. Human CYP3A4 protein expression was determined using an optimized hCYP3A4-HepG2 cell-based assay and the enzymatic activity was evaluated using P450-Glo CYP3A4 assay. The molecular interaction and possible inhibition of Deoxyelephantopin of the CYP3A4 enzyme was determined in silico and further validated using substrate-specific CYP3A4 inhibition assays. Deoxyelephantopin produced no significant effect on the CYP1A2 and CYP2D6 mRNA and protein expression. However, it has a weak induction effect on CYP3A4 at the transcriptional level[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 3.44 mg/mL (10 mM)


关键字: Akt | Inhibitor | β-catenin | MAPK | Nuclear factor-κB | Deoxyelephantopin | NF-κB | PI3K | Nuclear factor-kappaB | anticancer | inhibit

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相关库: Anti-Aging Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Anti-Breast Cancer Compound Library | Pyroptosis Compound Library | Inhibitor Library | Traditional Chinese Medicine Monomer Library | Anti-Pancreatic Cancer Compound Library | RO5 Drug-like Natural Product Library | Covalent Inhibitor Library | Bioactive Compound Library

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