3-O-乙酰基-16Α-羟基松苓新酸 TN1109

Product Introduction
Bioactivity


英文名: 3-O-Acetyl-16α-hydroxydehydrotrametenolic acid

描述: 3-O-Acetyl-16α-hydroxydehydrotrametenolic acid (3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid) 是三萜类化合物。它能够作用于 LPS 刺激的 Raw264.7 细胞，减少NO 产生和 iNOS 表达，具有消炎作用。

体外活性: Based on bioassay-guided fractionation using lipopolysaccharide (LPS)-stimulated Raw264.7 cells, chemical investigation of the EtOH extract of the sclerotia of P. cocos resulted in the isolation and identification of eight compounds including six triterpenoids, namely poricoic acid A (1), 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid(2), polyporenic acid C (3), 3β-hydroxylanosta-7,9(11),24-trien-21-oic acid (4), trametenolic acid (5), and dehydroeburicoic acid (6), as well as (-)-pinoresinol (7) and protocatechualdehyde (8). The structures of the isolated compounds were determined by spectroscopic analysis, including 1H and 13C NMR spectra, and LC/MS analysis. The anti-inflammatory activities of the isolates were evaluated by estimating their effect on the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in LPS-stimulated Raw264.7 as well as on the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Compounds 1-5 inhibited NO production and iNOS expression in LPS-stimulated Raw264.7 cells. Among them, compound 1 exerted the highest anti-inhibitory activity and reduced PGE2 levels via downregulation of COX-2 protein expression.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: 3-O-Acetyl-16α-hydroxydehydrotrametenolic acid | 3-O-Acetyl-16a-hydroxydehydrotrametenolic acid | triterpenoid | iNOS | NO Synthase | production | NOS | 3-O-Acetyl-16 a-hydroxydehydrotrametenolic acid | inhibit | Nitric oxide synthases | 3-O-Acetyl-16 α-hydroxydehydrotrametenolic acid | Inhibitor | Raw264.7 | anti-inflammatory | 3OAcetyl16αhydroxydehydrotrametenolic acid | 3 O Acetyl 16α hydroxydehydrotrametenolic acid

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途