吴茱萸卡品碱 TN1121

Product Introduction
Bioactivity


英文名: Evocarpine

描述: Evocarpine 是从 Evodiae fructus 分离得到的一种喹诺酮类生物碱，有抗细菌活性。它可通过电压依赖性钙通道抑制 Ca2+内流。

体外活性: The antimycobacterial and modulating activity of evodiamine (1), rutaecarpine (2) and Evocarpine (3) was tested on mycobacteria including three multidrug-resistant (MDR) clinical isolates of Mycobacterium tuberculosis. Antagonistic effects were concluded from fractional inhibitory concentration (FICI) values. Interaction energies of the compounds were calculated using GLUE docking module implemented in GRID. 1 and 2 exhibited weak inhibition of rapidly growing mycobacteria, however, 1 was active against Myco. tuberculosis H37Rv (MIC = 10 mg l(-1) ) while 2 was inactive. Both 1 and 2 showed a marked antagonistic effect on the susceptibility of different mycobacterial strains to 3 giving FICI values between 5 and 9. The interaction energies between compounds 1 and 2 with compound 3 suggested the possibility of complex formation in solution[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (147.27 mM)


关键字: Ca2+ | HL-60 | inhibit | antimycobacterial | Inhibitor | Evocarpine | leukaemia | Bacterial | Apoptosis | Influx

相关产品: Ionomycin calcium | SKI II | Fedratinib hydrochloride hydrate | Ganetespib | GSK1059615 | DCH36_06 | GW 441756 | Epothilone A | SM-164 | Clobenpropit dihydrobromide

相关库: Anti-Tumor Natural Product Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Alkaloid Natural Product Library | Traditional Chinese Medicine Monomer Library | Natural Product Library for HTS | Metabolism Compound Library | Bioactive Compound Library | Anti-Infection Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途