远志皂苷B TN1140
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mg | 35906-36-6 | ¥987.00 | 询底价 |
1 mg | 35906-36-6 | ¥247.00 | 询底价 |
1 mL | 35906-36-6 | ¥1,390.00 | 询底价 |
25 mg | 35906-36-6 | ¥1,690.00 | 询底价 |
50 mg | 35906-36-6 | 面议 | 询底价 |
5 mg | 35906-36-6 | ¥678.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Onjisaponin B
描述: Onjisaponin B 是从远志中提取的一种天然产物,可通过 AMPK-mTOR 信号通路诱导自噬,提高 NGF 水平并加速突变型亨廷顿蛋白和 A53T α±-突触核蛋白的清除,可研究帕金森病和亨廷顿病。
体外活性: In the current study, we aimed to identify autophagy inducers from Chinese medicinal herbs as a potential neuroprotective agent that enhances the clearance of mutant huntingtin and α±-synuclein in PC-12 cells. Through intensive screening using the green fluorescent protein-light chain 3 (GFP-LC3) autophagy detection platform, we found that the ethanol extracts of Radix Polygalae (Yuan Zhi) were capable of inducing autophagy. Further investigation showed that among three single components derived from Radix Polygalae--i.e., polygalacic acid, senegenin and Onjisaponin B--Onjisaponin B was able to induce autophagy and accelerate both the removal of mutant huntingtin and A53T α±-synuclein, which are highly associated with Huntington disease and Parkinson disease, respectively. Our study further demonstrated that Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway[1]
存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 50 mg/mL (31.77 mM)
关键字: Autophagy | Onjisaponin B | Inhibitor | inhibit
相关产品: Brazilin | Glycycoumarin | Pomolic acid | Mogrol | YKL-06-061 | MT 63-78 | EX229 | Platycodin D | GSK-1070916 | Kudinoside D
相关库: Antioxidant Compound Library | Anti-Tumor Natural Product Library | AMPK-Targeted Compound Library | Anti-Cancer Compound Library | Selected Plant-Sourced Compound Library | Anti-Metabolism Disease Compound Library | Anti-Obesity Compound Library | Anti-Diabetic Compound Library | Traditional Chinese Medicine Monomer Library | Natural Product Library for HTS
远志皂苷B TN1140信息由TargetMol中国为您提供,如您想了解更多关于远志皂苷B TN1140报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途