原花青素 B3 TN1150

Product Introduction
Bioactivity


英文名: Procyanidin B3

描述: Procyanidin B3 是从葡萄中提取的一种黄酮类天然产物，是组蛋白乙酰转移酶特异性抑制剂，可与 p300的其他位点而非活性位点结合，选择性抑制 p300 介导的 androgen 受体乙酰化。

体外活性: We observed that Procyanidin B3 inhibited H(2)O(2)-induced apoptosis in primary chondrocytes, suppressed H(2)O(2)- or IL-1?-induced nitric oxide synthase (iNOS) production, and prevented IL-1?-induced suppression of chondrocyte differentiation marker gene expression in primary chondrocytes. Moreover, Procyanidin B3 treatment enhanced the early differentiation of ATDC5 cells. To examine whether Procyanidin B3 prevents cartilage destruction in vivo, OA was surgically induced in C57BL/6J mice followed by oral administration of Procyanidin B3 or vehicle control. Daily oral Procyanidin B3 administration protected articular cartilage from OA and prevented chondrocyte apoptosis in surgically-induced OA joints. Furthermore, Procyanidin B3 administration prevented heterotopic cartilage formation near the surgical region. iNOS protein expression was enhanced in the synovial tissues and the pseudocapsule around the surgical region in OA mice fed a control diet, but was reduced in mice that received Procyanidin B3. Together, these data indicated that in the OA model, Procyanidin B3 prevented OA progression and heterotopic cartilage formation, at least in a part through the suppression of iNOS.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 10 mg/mL (17.29 mM)


关键字: Histone Acetyltransferase | Procyanidin B-3 | Procyanidin B 3 | HAT | HATs | inhibit | Inhibitor | Procyanidin B3

相关产品: PF-CBP1 hydrochloride | Remodelin | SGC-CBP30 | EML 425 | NEO2734 | MOZ-IN-3 | CTPB | CPTH2 | MG 149 | CTX-0124143

相关库: Anti-Hypertension Compound Library | Oxidation-Reduction Compound Library | Polyphenolic Natural Product Library | Chinese Pharmacopoeia Natural Product Library | Bioactive Compounds Library Max | Ferroptosis Compound Library | Inhibitor Library | Traditional Chinese Medicine Monomer Library | Miao medicine Compound Library | Food as Medicine Compound Library

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