左旋箭毒碱 TN1156

Product Introduction
Bioactivity


英文名: (-)-Curine

描述: (-)-Curine can inhibit viability of hepatocellular carcinoma cells in regardless of p53 status.

体外活性: As in many other cancers, p53 mutations are commonly observed in HCCs (Hussain et al., 2007; Levine et al., 1994) [1,2]. Tumor tissues with mutant p53 seems to be more aggressive and resist to chemotherapy than that harboring wide-type p53 (Harris and Hollstein, 1994; Parrales and Iwakuma, 2015) [3,4]. (-)-Curine, a novel bisbenzylisoquinoline alkaloid, is one of the main components isolated from the roots of Cyclea wattii. Here, it was found to exert cytotoxity on hepatocellular carcinoma (HCC) cells regardless of p53 status. We found that (-)-Curine induced G1 arrest and cell death in HepG2 cells with wild-type p53 as well as Huh-7 cells with mutant p53. In HepG2 cells, knocking down of p53 did not change its cellular responses to (-)-Curine, and same degree of G1 arrest and cell death were occurred after p53 knockdown.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: ( ) Curine | Curine | ()Curine

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途