左旋-α-蒎烯 TN1202

Product Introduction
Bioactivity


英文名: (-)-α-Pinene

描述: (-)-α-Pinene ((1S)-(-)-Alpha-Pinene) 是一种单萜类化合物，通过延长 GABAergic 突触传递、作为 GABAA-BZD 受体的部分调节剂并直接与 GABAA 受体的 BZD 结合位点结合来增强 NREMS 的数量而不影响 NREMS 的强度。

体外活性: (1S)-(-)-Alpha-Pinene significantly increased the duration of non-rapid eye movement sleep (NREMS) and reduced the sleep latency by oral administration without affecting duration of rapid eye movement sleep and delta activity. (1S)-(-)-Alpha-Pinene potentiated the GABAA receptor-mediated synaptic response by increasing the decay time constant of sIPSCs in hippocampal CA1 pyramidal neurons[1]. These effects of (1S)-(-)-Alpha-Pinene on sleep and inhibitory synaptic response were mimicked by zolpidem, acting as a modulator for GABAA-BZD receptors, and fully antagonized by flumazenil, an antagonist for GABAA-BZD receptor. (1S)-(-)-Alpha-Pinene was found to bind to aromatic residues of α1- and -γ2 subunits of GABAA-BZD receptors in the molecular model[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (367.03 mM)


关键字: Gamma-aminobutyric acid Receptor | ()αPinene | Bacterial | Virus Protease | Endogenous Metabolite | γ-Aminobutyric acid Receptor | a-Pinene | α-Pinene | Alpha-Pinene | ( ) α Pinene | GABA Receptor | inhibit | Inhibitor

相关产品: Schisandrin C | Novobiocin | Plerixafor octahydrochloride | SP187 | NGI-1 | NS2B-NS3pro-IN-2 | Retro-2 cycl | A2ti-2 | Ebselen | Genkwanin

相关库: Tobacco Monomer Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Traditional Chinese Medicine Monomer Library | Miao medicine Compound Library | Antiparasitic Natural Product Library | Microbial Natural Product Library | Natural Product Library | Bioactive Compound Library

左旋-α-蒎烯 TN1202信息由TargetMol中国为您提供，如您想了解更多关于左旋-α-蒎烯 TN1202报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途