2,3-脱氢维酮 TN1204

Product Introduction
Bioactivity


英文名: 2,3-Dehydrokievitone

描述: 2,3-Dehydrokievitone 是一种从刺桐属植物 Erythrina sacleuxii 中提取的一种异黄酮，具有抗菌活性，可通过降低α-溶血素表达来对抗耐甲氧西林金黄色葡萄球菌感染。

体外活性: To evaluate the anti-oxidative effects of these compounds, their 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging assays and nitrotetrazolium blue chloride (NBT) superoxide scavenging assays were measured. And the anti-tumor activity against human cancer cell lines in genital system, LNCaP, PC-3,HeLa and OVCAR-3 cells were evaluated by MTT method. Furthermore, the apoptosis of the PC-3 and HeLa cells were determined by by annexin V-FITC and PI their fluorescence was analyzed by flow cytometry. The flavonol (9, isoquercitrin) and pterocarpan (8, 4-hydroxymaackiain) showed strong anti-oxidative activities. Besides, the isoflavones (1-5) did not showed anti-oxidative activity and the isoflavones (1-5) and pterocarpans (6-8) generally showed the potent cytotoxic activity against all of four human genital cancer cells. Especially, 2,3-Dehydrokievitone (5) which had a prenyl group at C-8 position of the A-ring exhibited strong cytotoxic activity and induced apoptosis efficiently in cancer cells.

存储条件: store at low temperature,keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: 2,3-Dehydrokievitone | 2,3 Dehydrokievitone | 2,3Dehydrokievitone

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途