2-羟基-1-甲氧基阿朴啡 TN1210

Product Introduction
Bioactivity


英文名: 2-Hydroxy-1-Methoxyaporphine

描述: 2-Hydroxy-1-Methoxyaporphine can inhibit CYP2D6 activity, it also increase the glucose consumption significantly as rosiglitazone.

体外活性: In order to produce large amounts of pure alkaloid for research purposes, a novel method using high-speed counter-current chromatography (HSCCC) was developed. Without any initial cleanup steps, four main aporphine alkaloids, including 2-Hydroxy-1-Methoxyaporphine, pronuciferine, nuciferine and roemerine were successfully purified from the crude extract by HSCCC in one step. The separation was performed with a simple two-phase solvent system composed of n-hexane-ethyl acetate-methanol-acetonitrile-water (5:3:3:2.5:5, v/v/v/v/v). In each operation, 100 mg crude extracts was separated and yielded 6.3 mg of 2-Hydroxy-1-Methoxyaporphine (95.1% purity), 1.1 mg of pronuciferine (96.8% purity), 8.5 mg of nuciferine (98.9% purity), and 2.7 mg of roemerine (97.4%) respectively. The chemical structure of four aporphine alkaloids are identified by means of electrospray ionization MS (ESI-MS) and nuclear magnetic resonance (NMR) analysis. Moreover, the effects of four separated aporphine alkaloids on insulin-stimulated glucose consumption were examined in 3T3-L1 adipocytes.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: 2 Hydroxy 1 Methoxyaporphine | 2-Hydroxy-1-Methoxyaporphine | 2Hydroxy1Methoxyaporphine

相关产品: TAK-700 | Quinidine sulfate dihydrate | BMS-819881 | Isavuconazole | Ginsenoside Rd | Talarozole | 6',7'-Dihydroxybergamottin | Chrysosplenetin | Atovaquone | Mefentrifluconazole

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