4',6,7-三羟基异黄酮 TN1299

Product Introduction
Bioactivity


英文名: Desmethylglycitein

描述: Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) 是大豆中苷元的代谢产物，具有抗氧化性和抗癌活性。它是蛋白激酶 C(PKC)α 的直接抑制剂，抑制正常人皮肤成纤维细胞中的太阳紫外线诱导的基质金属蛋白酶1。它在体内直接结合CDK1和CDK2，抑制 CDK1 和 CDK2 活性。

体外活性: Molecular studies showed that 6,7,4'-THIF significantly inhibited acetylcholinesterase and thiobarbituric acid reactive substance (TBARS) activities in the hippocampus of scopolamine-induced mice.In addition, immunohistochemistry and Western blot results revealed that 6,7,4'-THIF significantly increased brain-derived neurotrophic factor (BDNF) and phosphor cAMP response element binding (CREB) in the hippocampus of mice.?

体内活性: A single administration of 6,7,4'-THIF significantly improved scopolamine-induced cognitive dysfunction in these in vivo tests.?Moreover, treatment with 6,7,4'-THIF alone enhanced learning and memory performance in the same behavioral tests. 6,7,4'-THIF improves cognitive dysfunction induced by scopolamine and enhances learning and memory by activation of the cholinergic system and the p-CREB/BDNF signaling pathway in mice

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 125 mg/mL (462.55 mM)


关键字: PI3K | Inhibitor | 4',6,7-Trihydroxyisoflavone | Phosphoinositide 3-kinase | Cyclin dependent kinase | PKC | Desmethylglycitein | inhibit | CDK | Protein kinase C

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途