α-茄碱 TN1376

Product Introduction
Bioactivity


英文名: α-Solanine

描述: Alpha-Solanine alters antioxidative enzyme activities and MDA and PCO concentrations and GST activity in fat body and midgut.

体外活性: In this study, we inquired into the anti-carcinogenic effect of alpha-Solanine against human pancreatic cancer cells. We investigated the anti-carcinogenic effect of alpha-Solanine against human pancreatic cancer cells. In vitro, alpha-Solanine inhibited proliferation of PANC-1, sw1990, MIA PaCa-2 cells in a dose-dependent manner, as well as cell migration and invasion with atoxic doses. The expression of MMP-2/9, extracellular inducer of matrix metalloproteinase (EMMPRIN), CD44, eNOS and E-cadherin were suppressed by alpha-Solanine in PANC-1 cells. Moreover, significantly decreased vascular endothelial growth factor (VEGF) expression and tube formation of endothelial cells were discerned following alpha-Solanine treatment. Suppressed phosphorylation of Akt, mTOR, and Stat3, and strengthen phosphorylation of β-catenin was found, along with markedly decreased tran-nuclear of NF-κB, β-catenin and TCF-1. Following the administration of alpha-Solanine (6 μg/g for 2 weeks) in xenograft model, tumor volume and weight were decreased by 61% and 43% (p<0.05) respectively, showing decreased MMP-2/9, PCNA and VEGF expression.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: a-Solanine | αSolanine | α-Solanine | α Solanine

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途